Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet
of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of …

The spiral ligament in the cochlea has been suggested to play a significant role in the
pathophysiology of different etiologies of strial hearing loss. Spiral ligament fibrocytes …

The knowledge about the etiology and pathophysiology of sensorineural hearing loss
(SNHL) is still very limited. This study aims at the improvement of understanding different …

The cochlea of the mammalian inner ear contains an endolymph that exhibits an
endocochlear potential (EP) of+ 80 mV with a [K+] of 150 mM. This unusual extracellular …

Cochlear fibrocytes are a homeostatic supporting cell type embedded in the vascularized
extracellular matrix of the spiral ligament, within the lateral wall. Here, they participate in the …

Background: The cochlea produces an electric field potential essential for hair cell
transduction and hearing. This biological “battery” is situated in the lateral wall of the …

Background The pervasive Na/K-ATPase pump is highly expressed in the human cochlea
and is involved in the generation of the endocochlear potential as well as auditory nerve …

Incremental changes in ionic composition, solvent quality, and temperature can lead to
reversible and abrupt structural changes in many synthetic and biopolymer systems. In the …

Excitable cochlear hair cells convert the mechanical energy of sounds into the electrical
signals necessary for neurotransmission. The key process is cellular depolarization via K+ …

The mammalian cochlea is an intricately designed organ that is exquisitely sensitive to
sound. It possesses unique physical and chemical properties that permit this organ to …