The past decade has revolutionized our understanding of regulatory noncoding RNAs
(ncRNAs). Among the most recently identified ncRNAs are downstream-of-gene (DoG) …

Response to hyperthermia, highly conserved from bacteria to humans, involves
transcriptional upregulation of genes involved in battling the cytotoxicity caused by …

The RNA-binding proteins TDP-43 and FUS are tied as the third leading known genetic
cause for amyotrophic lateral sclerosis (ALS), and TDP-43 proteopathies are found in nearly …

Endogenous retroviruses and long terminal repeat (LTR) retrotransposons are mobile
genetic elements that are closely related to retroviruses. Desilenced endogenous …

Background Mounting evidence suggests several diseases and biological processes target
transcription termination to misregulate gene expression. Disruption of transcription …

Elevated temperatures activate a heat shock response (HSR) to protect cells from the
pathological effects of protein mis-folding, cellular mis-organization, organelle dysfunction …

Sexual dimorphism is a device that supports genetic diversity while providing selective
pressure against speciation. This phenomenon is at the core of sexually reproducing …

The nematode Caenorhabditis elegans are a powerful model system to study human
disease, with numerous experimental advantages including significant genetic and cellular …

The production of eukaryotic mRNA requires transcription by RNA polymerase (pol) II and co-
transcriptional processing, including capping, splicing, and cleavage and polyadenylation …

RNA sequencing is an approach to transcriptomic profiling that enables the detection of
differentially expressed genes in response to genetic mutation or experimental treatment …