Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

To be most effective anticancer drugs must penetrate tissue efficiently, reaching all the
cancer cells that comprise the target population in a concentration sufficient to exert a …

Chloroquine (CQ), N′-(7-chloroquinolin-4-yl)-N, N-diethyl-pentane-1, 4-diamine, is widely
used as an effective and safe anti-malarial and anti-rheumatoid agent. CQ was discovered …

The presence of a microenvironment within most tumours containing regions of low oxygen
tension or hypoxia has profound biological and therapeutic implications. Tumour hypoxia is …

Purpose: Potential causes of drug resistance in solid tumors include genetically determined
factors expressed in individual cells and those related to the solid tumor environment …

To reach cancer cells in optimal quantities, therapeutic agents must be delivered to tumors
through their imperfect blood vascular system, cross vessel walls into the interstitium, and …

Anticancer prodrugs designed to target specifically tumor cells should increase therapeutic
effectiveness and decrease systemic side effects in the treatment of cancer. Over the last 20 …

Purpose: Limited drug penetration in solid tumors is a potential mechanism of resistance for
many anticancer drugs. Taxanes represent a class of drugs that are currently undergoing a …

In this study, an in vitro multicellular tumor spheroid model was developed using
microencapsulation, and the feasibility of using the microencapsulated multicellular tumor …

Limited penetration of antineoplastic agents is one of the contributing factors for
chemotherapy failure of many solid tumors. In order to enhance drug penetration into solid …