BACKGROUND Endometriosis is recognized as a steroid-dependent disorder; however, the
precise roles of nuclear receptors (NRs) in steroid responsiveness and other signaling …

Endometriosis is an estrogen-dependent disease. The biologically active estrogen,
estradiol, aggravates the pathological processes (eg, inflammation and growth) and the …

Arginine vasopressin (AVP) and oxytocin (OXT) are social hormones and mediate affiliative
behaviors in mammals and as recently demonstrated, also in humans. There is intense …

Loss of progesterone signaling in the endometrium may be a causal factor in the
development of endometriosis, and progesterone resistance is commonly observed in …

Obesity has been associated with abnormally high expression of the enzyme aromatase in
the breast, increased local estrogen production, and predisposition to breast hyperplasia …

The involvement of estrogen and its receptors in the development of cancer has been known
for years. However, the exact mechanism responsible is far from clear. The estrogen …

Context: Products of at least five specific steroidogenic genes, including steroidogenic acute
regulatory protein (StAR), which facilitates the entry of cytosolic cholesterol into the …

Background Wnt-11 is a secreted protein that modulates cell growth, differentiation and
morphogenesis during development. We previously reported that Wnt-11 expression is …

Context: Estradiol and its nuclear receptors, estrogen receptor (ER) α and ERβ, play critical
roles in endometrium and endometriosis. Levels of ERβ, due to pathological …

Endocrine therapy is important for management of patients with estrogen receptor (ER)–
positive breast cancer; however, positive ER staining does not reliably predict therapy …