Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …

The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

NAD is a vital molecule in all organisms. It is a key component of both energy and signal
transduction—processes that undergo crucial changes in cancer cells. NAD+-dependent …

Tumours with specific DNA repair defects can be completely dependent on back-up DNA
repair pathways for their survival. This dependence can be exploited therapeutically to …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Mammalian sirtuins have emerged in recent years as critical modulators of multiple
biological processes, regulating cellular metabolism, DNA repair, gene expression, and …

The sirtuins are a highly conserved family of NAD+-dependent enzymes that regulate
lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an …

Aging is accompanied by a decline in the healthy function of multiple organ systems, leading
to increased incidence and mortality from diseases such as type II diabetes mellitus …

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …