The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …

Mosquito-borne diseases are responsible for significant human morbidity and mortality
throughout the world. Efforts to control mosquito-borne diseases have been impeded, in …

Calcium controls many critical events in the complex life cycles of apicomplexan parasites
including protein secretion, motility, and development. Calcium levels are normally tightly …

Background Saliva of blood-sucking arthropods contains a cocktail of antihemostatic agents
and immunomodulators that help blood feeding. Mosquitoes additionally feed on sugar …

Malaria parasite transmission requires differentiation of male and female gametocytes into
gametes within a mosquito following a blood meal. A mosquito-derived molecule …

Abstract The heme enzyme indoleamine 2, 3-dioxygenase (IDO) oxidizes the pyrrole moiety
of L-tryptophan (Trp) and other indoleamines and represents the initial and rate-limiting …

Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

Plasmodium spp. undergo a complex obligate developmental cycle within their invertebrate
vectors that enables transmission between vertebrate hosts. This developmental cycle …

The tropical disease malaria, which results in more than one million deaths annually, is
caused by protozoan parasites of the genus Plasmodium and transmitted by blood‐feeding …

The sexual phase of the malaria pathogen, Plasmodium falciparum, culminates in
fertilization within the midgut of the mosquito and represents a crucial step in the completion …