Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection

L Pardo-López, M Soberón… - FEMS microbiology …, 2013 - academic.oup.com
Bacillus thuringiensis bacteria are insect pathogens that produce different Cry and Cyt toxins
to kill their hosts. Here we review the group of three-domain Cry (3d-Cry) toxins. Expression …

Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control

A Bravo, SS Gill, M Soberón - Toxicon, 2007 - Elsevier
Bacillus thuringiensis Crystal (Cry) and Cytolitic (Cyt) protein families are a diverse group of
proteins with activity against insects of different orders—Lepidoptera, Coleoptera, Diptera …

Current models of the mode of action of Bacillus thuringiensis insecticidal crystal proteins: a critical review

V Vachon, R Laprade, JL Schwartz - Journal of invertebrate pathology, 2012 - Elsevier
Bacillus thuringiensis (Bt) Cry toxins constitute the active ingredient in the most widely used
biological insecticides and insect-resistant transgenic crops. A clear understanding of their …

Cytotoxicity of Bacillus thuringiensis Cry1Ab toxin depends on specific binding of the toxin to the cadherin receptor BT-R1 expressed in insect cells

X Zhang, M Candas, NB Griko, L Rose-Young… - Cell Death & …, 2005 - nature.com
The specific role of cadherin receptors in cytotoxicity involving Cry toxins of Bacillus
thuringiensis and their interactions with cell membrane has not been defined. To elucidate …

Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin

I Arenas, A Bravo, M Soberón, I Gómez - Journal of biological chemistry, 2010 - ASBMB
Cry toxins produced by Bacillus thuringiensis have been recognized as pore-forming toxins
whose primary action is to lyse midgut epithelial cells in their target insect. In the case of the …

Pore formation by Cry toxins

M Soberón, L Pardo, C Muñóz-Garay… - … membrane binding and …, 2010 - Springer
B acillus thuringiensis (Bt) bacteria produce insecticidal Cry and Cyt proteins used in the
biological control of different insect pests. In this review, we will focus on the 3d-Cry toxins …

Insecticidal genetically modified crops and insect resistance management (IRM)

J Ferré, J Van Rie, SC MacIntosh - Integration of insect-resistant …, 2008 - Springer
Economically important crops, such as maize and cotton, have been transformed with genes
encoding insecticidal proteins from Bacillus thuringiensis (Bt) to confer them protection …

Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non-toxic to Manduca sexta larvae

N Jiménez-Juárez, C Muñoz-Garay, I Gómez… - Journal of Biological …, 2007 - ASBMB
Pore-forming toxins are biological weapons produced by a variety of living organisms,
particularly bacteria but also by insects, reptiles, and invertebrates. These proteins affect the …

Bacillus thuringiensis ssp. israelensis Cyt1Aa enhances activity of Cry11Aa toxin by facilitating the formation of a pre‐pore oligomeric structure

C Pérez, C Muñoz‐Garay, LC Portugal… - Cellular …, 2007 - Wiley Online Library
Bacillus thuringiensis ssp. israelensis (Bti) has been used worldwide for the control of
dipteran insect pests. This bacterium produces several Cry and Cyt toxins that individually …

Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products

A Armstrong, K Horry, T Cui, M Hulley, R Turner… - … of Chromatography A, 2021 - Elsevier
Recent advances in process analytical technologies and modelling techniques present
opportunities to improve industrial chromatography control strategies to enhance process …