Exploring the design of clinical research studies on the efficacy mechanisms in type 2 diabetes mellitus
H Guan, S Zhao, J Li, Y Wang, P Niu… - Frontiers in …, 2024 - frontiersin.org
This review examines the complexities of Type 2 Diabetes Mellitus (T2DM), focusing on the
critical role of integrating omics technologies with traditional experimental methods. It …
critical role of integrating omics technologies with traditional experimental methods. It …
Network Mendelian randomisation analysis deciphers protein pathways linking type 2 diabetes and gastrointestinal disease
J Geng, X Ruan, X Wu, X Chen, T Fu… - Diabetes, Obesity …, 2025 - Wiley Online Library
Aims The molecular mechanisms underlying the association between type 2 diabetes (T2D)
and gastrointestinal (GI) disease are unclear. To identify protein pathways, we conducted a …
and gastrointestinal (GI) disease are unclear. To identify protein pathways, we conducted a …
Microbial and proteomic signatures of type 2 diabetes in an Arab population
Background The rising prevalence of Type 2 diabetes mellitus (T2D) in the Qatari population
presents a significant public health challenge, highlighting the need for innovative …
presents a significant public health challenge, highlighting the need for innovative …
Proteomic analysis identifies novel biological pathways that may link dietary quality to type 2 diabetes risk: evidence from African American and Asian cohorts
CGY Lim, V Gradinariu, Y Liang, CM Rebholz… - The American Journal of …, 2025 - Elsevier
Background Diet affects the development of chronic diseases such as type 2 diabetes, but
the underlying biological mechanisms are only partly understood. Objectives This study …
the underlying biological mechanisms are only partly understood. Objectives This study …
Bidirectional Mendelian randomization highlights causal relationships between circulating INHBC and multiple cardiometabolic diseases and traits
NY Loh, DB Rosoff, R Richmond, R Noordam… - Diabetes, 2024 - diabetesjournals.org
Human genetic and transgenic mouse studies have highlighted a potential liver-adipose
tissue endocrine axis, involving activin C (Act-C) and/or Act-E and ALK7, influencing fat …
tissue endocrine axis, involving activin C (Act-C) and/or Act-E and ALK7, influencing fat …
Examination of the Complex Molecular Landscape in Obesity and Type 2 Diabetes
The escalating prevalence of metabolic disorders, notably type 2 diabetes (T2D) and
obesity, presents a critical global health challenge, necessitating deeper insights into their …
obesity, presents a critical global health challenge, necessitating deeper insights into their …