Adenoviral (Ad) vectors have emerged as a promising gene delivery platform for a variety of
therapeutic and vaccine purposes during last two decades. However, the presence of …

Adenovirus is a highly evolutionary successful pathogen, as it is widely prevalent across the
animal kingdom, infecting hosts ranging from lizards and frogs to dolphins, birds, and …

Polymer micelles are one of the most investigated nanocarriers for drug delivery; many have
entered clinical trials and some are in clinic use, but their delivery systems have not yet …

Nanoparticles (NPs) are versatile scaffolds for numerous biomedical applications including
drug delivery and bioimaging. The surface functionality of NPs essentially dictates …

Nonviral delivery of plasmid (p) DNA or messenger (m) RNA is a safe and promising
therapeutic option to continuously supply therapeutic proteins into diseased tissues. In most …

Adenovirus is a robust vector for therapeutic applications, but its use is limited by our
understanding of its complex in vivo pharmacology. In this review we describe the necessity …

Despite tremendous interest in gene therapies, the systemic delivery of nucleic acids still
faces substantial challenges. To successfully administer nucleic acids, one approach is to …

Kupffer cells (KCs) rapidly remove intravenously injected adenovirus (Ad) vectors from the
circulation. A better understanding of the mechanisms involved could suggest strategies to …

Polymersomes have the potential to encapsulate and deliver chemotherapeutic drugs into
tumor cells, reducing off-target toxicity that often compromises anticancer treatment. Here …

A major critical issue in systemically administered nanomedicines is nonspecific clearance
by the liver sinusoidal endothelium, causing a substantial decrease in the delivery efficiency …