Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Hypoxia increases patient treatment resistance and favors cancer progression. Nanozymes
have received unprecedented attention in alleviating hypoxia via catalase (CAT)-mimicking …

Extending the durability of response is the current focus in cancer immunotherapy with
immune checkpoint inhibitors (ICIs). However, factors like non-immunogenic tumor …

Hypoxia is a persistent physiological feature of many different solid tumors and a key driver
of malignancy, and in recent years, it has been recognized as an important target for cancer …

Long noncoding RNAs (lncRNA) regulate a number of aspects of cancer biology. Recent
research has shown that lncRNAs can encode micropeptides that mediate their functions in …

Fatty acid uptake is essential for cell physiological function, but detailed mechanisms remain
unclear. Here, we generated an acetyl-CoA carboxylases (ACC1/2) double-knockout cell …