Cell death plays a prominent role in the treatment of cancer, because most anticancer
therapies act by the induction of cell death including apoptosis, necrosis, and other …

Background: The incorporation of radionuclides into peptides and larger biomolecules
requires efficient and sometimes biorthogonal reaction conditions, to which click chemistry …

Purpose Many patients worldwide suffer from cardiovascular diseases for which an
underlying factor is thrombosis. Devising a molecular imaging technique for early detection …

Background Integrins are interesting targets in oncology. RGD sequence has high affinity for
α V β 3 integrin receptors. Diagnostic/therapeutic agents can be selectively delivered into …

Pretargeted concept in positron emission tomography (PET) together with bioorthogonal
chemistry is an elegant solution to study processes with slow pharmacokinetics by utilizing …

Objective Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by the
accumulation of extracellular matrix. Because there is no effective treatment for advanced …

Apoptosis is a regulated cell death induced by extrinsic and intrinsic stimulants. Tracking of
apoptosis provides an opportunity for the assessment of cardiovascular and …

One of the early biochemical changes of apoptotic cells is exposure of phosphatidylserine
on the external surface of the plasma membrane. The aim of current study is targeting …

Background: Early detection of apoptosis is very important for therapy and follow-up
treatment in various pathologic conditions. Annexin V interacts strongly and specifically with …

This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small
peptide, with [18 F] FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO …