More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast
cells form a heterogeneous population of immune cells with differences in their ultra …

Mast cells (MC s) are innate immune cells that are scattered in tissues throughout the
organism being particularly abundant at sites exposed to the environment such as the skin …

Mast cells (MCs) play critical roles in Th2 immune responses, including the defense against
parasitic infections and the initiation of type I allergic reactions. In addition, MCs are involved …

Mast cells and basophils are key contributors to allergies and other inflammatory diseases
since they are the most prominent source of histamine as well as numerous additional …

The pathophysiological roles of mast cells are still not fully understood, over 140 years since
their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct …

Mast cells and basophils represent the most relevant source of histamine in the immune
system. Histamine is stored in cytoplasmic granules along with other amines (eg, serotonin) …

Human mast cells (MCs) and eosinophils were first described and named by Paul Ehrlich.
These cells have distinct myeloid progenitors and differ morphologically, ultrastructurally …

Interleukin-33 (IL-33) is a IL-1 family member of cytokines exerting pleiotropic activities. In
the steady-state, IL-33 is expressed in the nucleus of epithelial, endothelial, and fibroblast …

Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are
strategically located in different compartments of human lung, where they play a role in …