Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
VD D'Agati, A Chagnac, AP De Vries, M Levi… - Nature Reviews …, 2016 - nature.com
The prevalence of obesity-related glomerulopathy is increasing in parallel with the
worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental …
worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental …
Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
Acquisition of dynamic function in human stem cell-derived β cells
Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …
Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion
Obesity and diabetes are associated with excess caloric intake and reduced energy
expenditure resulting in a negative energy balance. The incidence of diabetes has reached …
expenditure resulting in a negative energy balance. The incidence of diabetes has reached …
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin …
Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling
Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of
obesity and diabetes. Here, we illustrate an important role of the TGF-β/Smad3 signaling …
obesity and diabetes. Here, we illustrate an important role of the TGF-β/Smad3 signaling …
Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy
Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …
Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets
Background Epigenetic factors regulate tissue-specific expression and X-chromosome
inactivation. Previous studies have identified epigenetic differences between sexes in some …
inactivation. Previous studies have identified epigenetic differences between sexes in some …
[PDF][PDF] Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice
Transforming growth factor beta (TGF‐β) signaling activates Smad‐and TGF‐β‐activated
kinase 1 (TAK1)‐dependent signaling to regulate cell survival, proliferation, fibrosis, and …
kinase 1 (TAK1)‐dependent signaling to regulate cell survival, proliferation, fibrosis, and …
A circular RNA generated from an intron of the insulin gene controls insulin secretion
L Stoll, A Rodríguez-Trejo, C Guay, F Brozzi… - Nature …, 2020 - nature.com
Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose
homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing …
homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing …