O-GlcNAcylation—the attachment of O-linked N-acetylglucosamine (O-GlcNAc) moieties to
cytoplasmic, nuclear and mitochondrial proteins—is a post-translational modification that …

During the perinatal period, the brain is particularly sensitive to remodelling by
environmental factors. Adverse early‐life experiences, such as stress exposure or …

O-GlcNAcylation, which is a nutrient-sensitive sugar modification, participates in the
epigenetic regulation of gene expression. The enzymes involved in O-linked β-dN …

Circadian clocks are coupled to metabolic oscillations through nutrient-sensing pathways.
Nutrient flux into the hexosamine biosynthesis pathway triggers covalent protein …

Glucocorticoids (GCs) have been widely used for decades as a first-line treatment for
inflammatory and autoimmune diseases. However, their use is often hampered by the onset …

Maternal stress is a key risk factor in neurodevelopmental disorders, which often have a sex
bias in severity and prevalence. We previously identified O-GlcNAc transferase (OGT) as a …

Glucocorticoids (GCs) are commonly used in the treatment of a wide range of rheumatic and
other inflammatory diseases. They exert their potent anti-inflammatory and …

O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) catalyze the dynamic cycling of
intracellular, post-translational O-GlcNAc modification on thousands of Ser/Thr residues of …

Background & Aims Cerebral oxidative stress plays an important role in the pathogenesis of
hepatic encephalopathy (HE), but the underlying mechanisms are incompletely understood …

The circadian clock represents an anticipatory mechanism, well preserved in evolution. It
has a critical impact on most aspects of the physiology of light-sensitive organisms. These …