Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer
Metastasis is a complex process that requires the interaction between tumor cells and their
microenvironment. As an important regulator of intestinal microenvironment, gut microbiota …
microenvironment. As an important regulator of intestinal microenvironment, gut microbiota …
The microbiota and the gut–liver axis in primary sclerosing cholangitis
JR Hov, TH Karlsen - Nature Reviews Gastroenterology & Hepatology, 2023 - nature.com
Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …
owing to the close association between liver disease and colonic inflammation. It is well …
Microbial ecology perturbation in human IgA deficiency
J Fadlallah, H El Kafsi, D Sterlin, C Juste… - Science translational …, 2018 - science.org
Paradoxically, loss of immunoglobulin A (IgA), one of the most abundant antibodies, does
not irrevocably lead to severe infections in humans but rather is associated with relatively …
not irrevocably lead to severe infections in humans but rather is associated with relatively …
Non-infectious complications of common variable immunodeficiency: updated clinical spectrum, sequelae, and insights to pathogenesis
H Ho, C Cunningham-Rundles - Frontiers in immunology, 2020 - frontiersin.org
Non-infectious complications in common variable immunodeficiency (CVID) have emerged
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …
Determining gut microbial dysbiosis: a review of applied indexes for assessment of intestinal microbiota imbalances
Assessing “dysbiosis” in intestinal microbial communities is increasingly considered a
routine analysis in microbiota studies, and it has added relevant information to the prediction …
routine analysis in microbiota studies, and it has added relevant information to the prediction …
Common variable immunodeficiency: epidemiology, pathogenesis, clinical manifestations, diagnosis, classification, and management.
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by
hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is …
hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is …
Inborn errors of immunity: an expanding universe of disease and genetic architecture
YT Akalu, D Bogunovic - Nature Reviews Genetics, 2024 - nature.com
Inborn errors of immunity (IEIs) are generally considered to be rare monogenic disorders of
the immune system that cause immunodeficiency, autoinflammation, autoimmunity, allergy …
the immune system that cause immunodeficiency, autoinflammation, autoimmunity, allergy …
Current understanding and recent developments in common variable immunodeficiency associated autoimmunity
JD Gereige, PJ Maglione - Frontiers in immunology, 2019 - frontiersin.org
Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary
immunodeficiency and comprises a group of disorders with similar antibody deficiency but a …
immunodeficiency and comprises a group of disorders with similar antibody deficiency but a …
Incomplete penetrance in primary immunodeficiency: a skeleton in the closet
C Gruber, D Bogunovic - Human genetics, 2020 - Springer
Primary immunodeficiencies (PIDs) comprise a diverse group of over 400 genetic disorders
that result in clinically apparent immune dysfunction. Although PIDs are classically …
that result in clinically apparent immune dysfunction. Although PIDs are classically …