Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Current and future status of JAK inhibitors
DP McLornan, JE Pope, J Gotlib, CN Harrison - The lancet, 2021 - thelancet.com
An enhanced understanding of the importance of Janus kinase (JAK) and signal transducer
and activator of transcription (STAT) signalling in multiple disease states has led to an …
and activator of transcription (STAT) signalling in multiple disease states has led to an …
[HTML][HTML] Expansion of the global RNA virome reveals diverse clades of bacteriophages
High-throughput RNA sequencing offers broad opportunities to explore the Earth RNA
virome. Mining 5,150 diverse metatranscriptomes uncovered> 2.5 million RNA virus contigs …
virome. Mining 5,150 diverse metatranscriptomes uncovered> 2.5 million RNA virus contigs …
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
DE Johnson, RA O'Keefe, JR Grandis - Nature reviews Clinical …, 2018 - nature.com
Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …
and such hyperactivation is generally associated with a poor clinical prognosis. In the …
Role of JAK/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial–mesenchymal transition
W Jin - Cells, 2020 - mdpi.com
The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
[HTML][HTML] Regulation of the iron homeostatic hormone hepcidin
V Sangkhae, E Nemeth - Advances in nutrition, 2017 - Elsevier
Iron is required for many biological processes but is also toxic in excess; thus, body iron
balance is maintained through sophisticated regulatory mechanisms. The lack of a regulated …
balance is maintained through sophisticated regulatory mechanisms. The lack of a regulated …
Interferon-stimulated genes: a complex web of host defenses
WM Schneider, MD Chevillotte… - Annual review of …, 2014 - annualreviews.org
Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …
they are highly effective at resisting and controlling pathogens. In this review, we begin by …
Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but
their inappropriate activation also contributes to tissue damage during autoimmune and …
their inappropriate activation also contributes to tissue damage during autoimmune and …
The JAK-STAT pathway: from structural biology to cytokine engineering
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
serves as a paradigm for signal transduction from the extracellular environment to the …
serves as a paradigm for signal transduction from the extracellular environment to the …