Quality and quantity control of gene expression by nonsense-mediated mRNA decay

T Kurosaki, MW Popp, LE Maquat - Nature reviews Molecular cell …, 2019 - nature.com
Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …

Complexity of the alternative splicing landscape in plants

ASN Reddy, Y Marquez, M Kalyna, A Barta - The Plant Cell, 2013 - academic.oup.com
Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …

Alternative splicing and evolution: diversification, exon definition and function

H Keren, G Lev-Maor, G Ast - Nature Reviews Genetics, 2010 - nature.com
Over the past decade, it has been shown that alternative splicing (AS) is a major mechanism
for the enhancement of transcriptome and proteome diversity, particularly in mammals …

NMD: a multifaceted response to premature translational termination

S Kervestin, A Jacobson - Nature reviews Molecular cell biology, 2012 - nature.com
Although most mRNA molecules derived from protein-coding genes are destined to be
translated into functional polypeptides, some are eliminated by cellular quality control …

The exon junction complex as a node of post-transcriptional networks

HL Hir, J Saulière, Z Wang - Nature reviews Molecular cell biology, 2016 - nature.com
The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …

[HTML][HTML] Alternative splicing in plants–coming of age

NH Syed, M Kalyna, Y Marquez, A Barta… - Trends in plant …, 2012 - cell.com
More than 60% of intron-containing genes undergo alternative splicing (AS) in plants. This
number will increase when AS in different tissues, developmental stages, and environmental …

Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis

M Kalyna, CG Simpson, NH Syed… - Nucleic acids …, 2012 - academic.oup.com
Alternative splicing (AS) coupled to nonsense-mediated decay (NMD) is a post-
transcriptional mechanism for regulating gene expression. We have used a high-resolution …

Nonsense-mediated mRNA decay—mechanisms of substrate mRNA recognition and degradation in mammalian cells

C Schweingruber, SC Rufener, D Zünd… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-
coupled quality control system that recognizes and degrades aberrant mRNAs with …

Nonsense‐mediated mRNA decay: novel mechanistic insights and biological impact

ED Karousis, S Nasif… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
Nonsense‐mediated mRNA decay (NMD) was originally coined to define a quality control
mechanism that targets mRNAs with truncated open reading frames due to the presence of a …

Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression

S Nasif, L Contu, O Mühlemann - Seminars in cell & developmental biology, 2018 - Elsevier
Nonsense-mediated mRNA decay (NMD) has traditionally been described as a quality
control system that rids cells of aberrant mRNAs with crippled protein coding potential …