Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows organisms to increase their coding potential and regulate gene expression through multiple …
H Keren, G Lev-Maor, G Ast - Nature Reviews Genetics, 2010 - nature.com
Over the past decade, it has been shown that alternative splicing (AS) is a major mechanism for the enhancement of transcriptome and proteome diversity, particularly in mammals …
S Kervestin, A Jacobson - Nature reviews Molecular cell biology, 2012 - nature.com
Although most mRNA molecules derived from protein-coding genes are destined to be translated into functional polypeptides, some are eliminated by cellular quality control …
HL Hir, J Saulière, Z Wang - Nature reviews Molecular cell biology, 2016 - nature.com
The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …
More than 60% of intron-containing genes undergo alternative splicing (AS) in plants. This number will increase when AS in different tissues, developmental stages, and environmental …
Alternative splicing (AS) coupled to nonsense-mediated decay (NMD) is a post- transcriptional mechanism for regulating gene expression. We have used a high-resolution …
C Schweingruber, SC Rufener, D Zünd… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation- coupled quality control system that recognizes and degrades aberrant mRNAs with …
ED Karousis, S Nasif… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
Nonsense‐mediated mRNA decay (NMD) was originally coined to define a quality control mechanism that targets mRNAs with truncated open reading frames due to the presence of a …
S Nasif, L Contu, O Mühlemann - Seminars in cell & developmental biology, 2018 - Elsevier
Nonsense-mediated mRNA decay (NMD) has traditionally been described as a quality control system that rids cells of aberrant mRNAs with crippled protein coding potential …