Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential

S Yan, K Kotschenreuther, S Deng… - Cellular and molecular life …, 2022 - Springer
Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also
leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are …

Dysfunctions, molecular mechanisms, and therapeutic strategies of regulatory T cells in rheumatoid arthritis

X Li, H Xu, J Huang, D Luo, S Lv, X Lu… - Frontiers in …, 2021 - frontiersin.org
Regulatory T cells (Tregs) represent a distinct subpopulation of CD4+ T lymphocytes that
promote immune tolerance and maintain immune system homeostasis. The dysfunction of …

Circulating Baseline CXCR3+Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid …

JM Scheffler, C Drevinge, C Lindholm… - ACR open …, 2025 - Wiley Online Library
Objective The high prevalence of osteoporosis in rheumatoid arthritis (RA) is due to
inflammation that stimulates differentiation of osteoclasts, a process involving circulating …

Potential of neutrophil to lymphocyte ratio in predicting sustained remission in rheumatoid arthritis compared to other immune activation markers

S Chandrashekara, DC Lingaraju… - Indian Journal of …, 2020 - journals.lww.com
Methods: This prospective observational study involved newly diagnosed and treated RA
patients who fulfilled 2010 American College of Rheumatology (ACR)/European League …

Role of regulatory T cells in pathogenesis and therapeutics of rheumatoid arthritis and juvenile idiopathic arthritis

Y Feng, W Zhou, Y Qian, W Dong, L Tong… - Regulatory T Cells and …, 2024 - Elsevier
Regulatory T cells (Tregs) play a crucial role in maintaining immune system homeostasis
and promoting immune tolerance to autologous components. In the case of rheumatoid …

KLRG1 and its role in Rheumatoid Arthritis

C Thompson - 2019 - orca.cardiff.ac.uk
Introduction: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic joint
inflammation. A homeostatic disequilibrium of the immune system is implicated in the failure …