Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …

Neurovascular coupling reflects the close temporal and regional linkage between neural
activity and cerebral blood flow. Although providing mechanistic insight, our understanding …

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these
cells control blood flow is crucial for understanding how neural computation is powered, for …

This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF).
Evidence for reductions in O2 content (CaO2) rather than arterial O2 tension (PaO2) as the …

Prostaglandins are lipid-derived autacoids that modulate many physiological systems
including the CNS, cardiovascular, gastrointestinal, genitourinary, endocrine, respiratory …

Brain perfusion is tightly coupled to neuronal activity, is commonly used to monitor normal or
pathological brain function, and is a direct reflection of the interactions that occur between …

The involvement of the prostaglandin E2 (PGE2) system in cancer progression has long
been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with …

Neurovascular coupling is a crucial mechanism that matches the high energy demand of the
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E 2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

The brain possesses two intricate mechanisms that fulfill its continuous metabolic needs:
cerebral autoregulation, which ensures constant cerebral blood flow over a wide range of …