Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants

AJ Hampson, M Grimaldi… - Proceedings of the …, 1998 - National Acad Sciences
The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat
cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate …

Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum …

CD Rosenbaum, SP Carreiro, KM Babu - Journal of medical toxicology, 2012 - Springer
Despite their widespread Internet availability and use, many of the new drugs of abuse
remain unfamiliar to health care providers. The herbal marijuana alternatives, like K2 or …

Cannabidiol–recent advances

R Mechoulam, M Peters… - Chemistry & …, 2007 - Wiley Online Library
The aim of this review is to present some of the recent publications on cannabidiol (CBD; 2),
a major non‐psychoactive constituent of Cannabis, and to give a general overview. Special …

Neuroprotective effects of antioxidative flavonoids, quercetin,(+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten

H Dok-Go, KH Lee, HJ Kim, EH Lee, J Lee, YS Song… - Brain research, 2003 - Elsevier
The flavonoids quercetin,(+)-dihydroquercetin, and quercetin 3-methyl ether were isolated
from the ethyl acetate fractions of the fruits and stems of Opuntia ficus-indica var. saboten. In …

Intracellular molecular targets and signaling pathways involved in antioxidative and neuroprotective effects of cannabinoids in neurodegenerative conditions

A Tadijan, I Vlašić, J Vlainić, D Đikić, N Oršolić… - Antioxidants, 2022 - mdpi.com
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic
cannabinoids have received growing interest as treatment options in neurodegenerative …

Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial

AIR Maas, G Murray, H Henney, N Kassem… - The Lancet …, 2006 - thelancet.com
Background Traumatic brain injury is a major cause of death and disability. We sought to
assess the safety and efficacy of dexanabinol, a synthetic cannabinoid analogue devoid of …

Neuroprotective Antioxidants from Marijuanaa

AJ Hampson, M Grimaldi, M Lolic… - Annals of the New …, 2000 - Wiley Online Library
Cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical
neuron cultures exposed to toxic levels of the neurotransmitter, glutamate. The psychotropic …

Oxidative stress in closed-head injury: brain antioxidant capacity as an indicator of functional outcome

E Shohami, E Beit-Yannai… - Journal of Cerebral …, 1997 - journals.sagepub.com
It has been suggested that reactive oxygen species (ROS) play a role in the pathophysiology
of brain damage. A number of therapeutic approaches, based on scavenging these radicals …

[HTML][HTML] Activation of cannabinoid CB2 receptor–mediated AMPK/CREB pathway reduces cerebral ischemic injury

IY Choi, C Ju, AMAA Jalin, DI Lee, PL Prather… - The American journal of …, 2013 - Elsevier
The type 2 cannabinoid receptor (CB2R) was recently shown to mediate neuroprotection in
ischemic injury. However, the role of CB2Rs in the central nervous system, especially …