Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …

Cardiac hypertrophy is an adaptive response to physiological and pathological overload. In
response to the overload, individual cardiac myocytes become mechanically stretched and …

Cardiovascular disease (CVD) remains the leading cause of mortality globally, so further
investigation is required to identify its underlying mechanisms and potential targets for its …

Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer.
Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be …

Rationale: Despite a recent decline of in-hospital mortality attributable to acute myocardial
infarction (AMI), the incidence of ischemic heart failure (HF) in post-AMI patients is …

Cardiovascular regenerative therapies are pursued on both basic and translational levels.
Although efficacy and value of cell therapy for myocardial regeneration can be debated …

When cells sense a decrease in oxygen availability (hypoxia), they develop adaptive
responses in order to sustain this condition and survive. If hypoxia lasts too long or is too …

Hypoxia is a hallmark of solid tumors and plays a critical role in different steps of tumor
progression, including proliferation, survival, angiogenesis, metastasis, metabolic …

The ongoing contractile and metabolic demands of the heart require a tight control over
protein quality control, including the maintenance of protein folding, turnover and synthesis …

The STUB1 gene (STIP1 homology and U-box-containing protein 1), located at 16q13. 3,
encodes the CHIP (carboxyl terminus of Hsc70-interacting protein), an essential E3 ligase …