Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …

Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the
preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction …

It has been 200 years since Parkinson disease (PD) was described by Dr. Parkinson in
1817. The disease is the second most common neurodegenerative disease characterized …

Parkinson's disease (PD) is the second most common neurodegenerative disorder that is
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic …

Parkinson's disease (PD) is a heterogenous disease with a varying age of onset, symptoms,
and rate of progression. This heterogeneity requires the use of a variety of animal models to …

Mitophagy impairment and oxidative stress are cardinal pathological hallmarks in
Parkinson's disease (PD), a common age-related neurodegenerative condition. The specific …

Summary α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in
Parkinson's disease (PD). Developing disease-modifying therapies requires animal models …