Topical carbonic anhydrase inhibitors and glaucoma in 2021: where do we stand?

A Stoner, A Harris, F Oddone, A Belamkar… - British Journal of …, 2022 - bjo.bmj.com
Carbonic anhydrase inhibitors (CAIs) have been used for many decades in the treatment of
glaucoma. Systemic CAIs were an early treatment option to lower intraocular pressure by …

[HTML][HTML] Myocilin-associated glaucoma: a historical perspective and recent research progress

R Sharma, A Grover - Molecular Vision, 2021 - ncbi.nlm.nih.gov
Glaucoma a debilitating disease, is globally the second most common kind of permanent
blindness. Primary open-angle glaucoma (POAG) is its most prevalent form and is often …

[HTML][HTML] Ocular inflammation and oxidative stress as a result of chronic intermittent hypoxia: a rat model of sleep apnea

N Donkor, JJ Gardner, JL Bradshaw, RL Cunningham… - Antioxidants, 2024 - mdpi.com
Obstructive sleep apnea (OSA) is a sleep disorder characterized by intermittent complete or
partial occlusion of the airway. Despite a recognized association between OSA and …

Cubogel as potential platform for glaucoma management

S Sayed, M Abdel-Moteleb, MM Amin… - Drug delivery, 2021 - Taylor & Francis
The aim of this work is to survey the potential of cubogel as an ocular dosage form to boost
the corneal permeability of Dorzolamide Hydrochloride DZ; an antiglaucomal drug. DZ …

Precisional modulation of translaminar pressure gradients for ophthalmic diseases

E Waisberg, J Ong, M Masalkhi… - European Journal …, 2024 - journals.sagepub.com
The translaminar pressure gradient (TLPG) refers to two forces at the lamina cribosa of the
optic nerve: the anteriorly acting intracranial pressure (ICP), and posteriorly-acting …

Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open …

SK Pulukool, SKS Bhagavatham, V Kannan… - Scientific Reports, 2021 - nature.com
Glaucoma of which primary open angle glaucoma (POAG) constitutes 75%, is the second
leading cause of blindness. Elevated intra ocular pressure and Nitric oxide synthase (NOS) …

Current and new pharmacotherapeutic approaches for glaucoma

WS Shalaby, V Shankar, R Razeghinejad… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Glaucoma is the leading cause of irreversible blindness worldwide. Medical
therapy is the main line of treatment of open-angle glaucoma (OAG) and ocular …

A topical formulation of melatoninergic compounds exerts strong hypotensive and neuroprotective effects in a rat model of hypertensive glaucoma

M Dal Monte, M Cammalleri, R Amato… - International Journal of …, 2020 - mdpi.com
Melatonin is of great importance for regulating several eye processes, including pressure
homeostasis. Melatonin in combination with agomelatine has been recently reported to …

Dorzolamide/timolol fixed combination: learning from the past and looking toward the future

AG Konstas, L Schmetterer, A Katsanos… - Advances in …, 2021 - Springer
The key clinical attributes of preserved dorzolamide/timolol fixed combination (DTFC) and
the emerging potential of preservative-free (PF) DTFC are reviewed with published evidence …

[HTML][HTML] Phase I NT-501 ciliary neurotrophic factor implant trial for primary open-angle glaucoma: safety, neuroprotection, and neuroenhancement

JL Goldberg, G Beykin, KR Satterfield, M Nuñez… - Ophthalmology …, 2023 - Elsevier
Purpose To assess the safety and efficacy of a ciliary neurotrophic factor (CNTF) intraocular
implant on neuroprotection and neuroenhancement in glaucoma. Design Open-label …