Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Pulse radiolysis is a powerful method for generating highly reduced or oxidized species and
free radicals. Combined with fast time-resolved spectroscopic measurement, we can monitor …

Despite concerted functional genomic efforts to understand the complex phenotype of
ionizing radiation (IR) resistance, a genome sequence cannot predict whether a cell is IR …

A microfluidic chip integrated with a microelectrode and a cathodic photoelectrochemical
(PEC) biosensor for the ultrasensitive detection of non-small cell lung cancer cytokeratin …

Product inhibition poses a persistent challenge in catalysis, adversely affecting reaction
rates and selectivity, leading to substantial economic losses in industrial settings. This …

Manganese–peroxos are proposed as key intermediates in a number of important
biochemical and synthetic transformations. Our understanding of the structural …

Metastable Mn–peroxo species are proposed to form as key intermediates in biological
oxidation reactions involving O2 and C–H bond activation. The majority of these have yet to …

Human MnSOD is a homotetramer and represents an essential mitochondrial antioxidant
enzyme, which catalyzes the dismutation of superoxide radicals (O2˙−) at near diffusion …

Reduction of superoxide () by manganese-containing superoxide dismutase occurs through
either a “prompt protonation” pathway, or an “inner-sphere” pathway, with the latter leading …

Human MnSOD is significantly more product-inhibited than bacterial MnSODs at high
concentrations of superoxide (O2–). This behavior limits the amount of H2O2 produced at …