Remarkable progress has been made in defining a new understanding of the role of mRNA
translation and protein synthesis in human cancer. Translational control is a crucial …

The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has
received increased attention during recent years due to its emerging significance for many …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

The 5′ and 3′ untranslated regions (UTRs) regulate crucial aspects of post-transcriptional
gene regulation that are necessary for the maintenance of cellular homeostasis. When these …

Protein synthesis of an RNA template can start by two different known mechanisms: cap-
dependent translation initiation and cap-independent translation initiation. The latter is …

Recent work has brought to light many different mechanisms of translation initiation that
function in cells in parallel to canonical cap‐dependent initiation. This has important …

A growing body of work demonstrates the importance of post-transcriptional control, in
particular translation initiation, in the overall regulation of gene expression. Here we focus …

Deregulated expression of MYC is a driver of colorectal carcinogenesis, suggesting that
inhibiting MYC may have significant therapeutic value. The PI3K and mTOR pathways …

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide.
Metabolic reprogramming represents an important cancer hallmark in CRC. Reprogramming …