Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the
underlying molecular mechanisms remained unclear. The breakthrough discovery that the …

The amyloid β-protein (Aβ) is subject to proteolytic degradation by a diverse array of
peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A …

Despite decades of speculation that inhibiting endogenous insulin degradation might treat
type-2 diabetes,, and the identification of IDE (insulin-degrading enzyme) as a diabetes …

Recent genome-wide association studies demonstrated that common variants of solute
carrier family 30 member 8 gene (SLC30A8) increase susceptibility to type 2 diabetes …

Insulin‐degrading enzyme (IDE) function goes far beyond its known proteolytic role as a
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …

J. Neurochem.(2012) 120 (Suppl. 1), 167–185. Abstract The amyloid cascade hypothesis of
Alzheimer's disease envisages that the initial elevation of amyloid β‐peptide (Aβ) levels …

Insulin-degrading enzyme (IDE) is a major enzyme responsible for insulin degradation. In
addition to insulin, IDE degrades many targets including glucagon, atrial natriuretic peptide …

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …

The changes in the brain signaling systems play an important role in etiology and
pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a …

An environmentally friendly, versatile multicomponent reaction for synthesizing isoxazol-5-
one and pyrazol-3-one derivatives has been developed, utilizing a freshly prepared g-C3N4 …