Cross-feeding in the gut microbiome: ecology and mechanisms

EJ Culp, AL Goodman - Cell host & microbe, 2023 - cell.com
Microbial communities are shaped by positive and negative interactions ranging from
competition to mutualism. In the context of the mammalian gut and its microbial inhabitants …

Role of dietary nutrients in the modulation of gut microbiota: a narrative review

Q Yang, Q Liang, B Balakrishnan, DP Belobrajdic… - Nutrients, 2020 - mdpi.com
Understanding how dietary nutrients modulate the gut microbiome is of great interest for the
development of food products and eating patterns for combatting the global burden of non …

A single sulfatase is required to access colonic mucin by a gut bacterium

AS Luis, C Jin, GV Pereira, RWP Glowacki, SR Gugel… - Nature, 2021 - nature.com
Humans have co-evolved with a dense community of microbial symbionts that inhabit the
lower intestine. In the colon, secreted mucus creates a barrier that separates these …

A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1

W Li, S Hang, Y Fang, S Bae, Y Zhang, M Zhang… - Cell host & …, 2021 - cell.com
Bile acids act as signaling molecules that regulate immune homeostasis, including the
differentiation of CD4+ T cells into distinct T cell subsets. The bile acid metabolite …

Bacteria require phase separation for fitness in the mammalian gut

E Krypotou, GE Townsend, X Gao, S Tachiyama, J Liu… - Science, 2023 - science.org
Therapeutic manipulation of the gut microbiota holds great potential for human health. The
mechanisms bacteria use to colonize the gut therefore present valuable targets for clinical …

An insider's perspective: Bacteroides as a window into the microbiome

AG Wexler, AL Goodman - Nature microbiology, 2017 - nature.com
Over the last decade, our appreciation for the contribution of resident gut microorganisms—
the gut microbiota—to human health has surged. However, progress is limited by the sheer …

Separating host and microbiome contributions to drug pharmacokinetics and toxicity

M Zimmermann, M Zimmermann-Kogadeeva… - Science, 2019 - science.org
INTRODUCTION The gut microbiota is implicated in the metabolism of many medical drugs,
with consequences for interpersonal variation in drug efficacy and toxicity. However …

Ecology and evolution of metabolic cross-feeding interactions in bacteria

G D'Souza, S Shitut, D Preussger, G Yousif… - Natural product …, 2018 - pubs.rsc.org
Literature covered: early 2000s to late 2017 Bacteria frequently exchange metabolites with
other micro-and macro-organisms. In these often obligate cross-feeding interactions, primary …

The social network of microorganisms—how auxotrophies shape complex communities

K Zengler, LS Zaramela - Nature Reviews Microbiology, 2018 - nature.com
Microorganisms engage in complex interactions with other organisms and their
environment. Recent studies have shown that these interactions are not limited to the …

The evolution of cooperation within the gut microbiota

S Rakoff-Nahoum, KR Foster, LE Comstock - Nature, 2016 - nature.com
Cooperative phenotypes are considered central to the functioning of microbial communities
in many contexts, including communication via quorum sensing, biofilm formation, antibiotic …