Cholinergic neurons comprise a small population of cells in the striatum but have
fundamental roles in fine tuning brain function, and in the etiology of neurological and …

Huntington's disease (HD) is a hereditary progressive neurodegenerative disorder caused
by a CAG repeat expansion in the gene coding for the protein huntingtin, resulting in a …

Objective: Pediatric obsessive-compulsive disorder (OCD) sometimes appears rapidly, even
overnight, often after an infection. Pediatric autoimmune neuropsychiatric disorders …

We previously reported a new line of Shank3 mutant mice which led to a complete loss of
Shank3 by deleting exons 4− 22 (Δe4− 22) globally. Δe4− 22 mice display robust ASD-like …

Dysregulation of habit formation has been recently proposed as pivotal to eating disorders.
Here, we report that a subset of patients suffering from restrictive anorexia nervosa have …

Currently, it is possible to study the pathogenesis of Tourette's syndrome (TS) in more detail,
due to more advanced methods of neuroimaging. However, medical and surgical treatment …

Background Deficient social interactions are a hallmark of major neuropsychiatric disorders,
and accumulating evidence points to altered social reward and motivation as key underlying …

Cholinergic interneurons are “gatekeepers” for striatal circuitry and play pivotal roles in
attention, goal-directed actions, habit formation, and behavioral flexibility. Accordingly …

Tourette syndrome is a common neurodevelopmental disorder defined by characteristic
involuntary movements, tics, with both motor and phonic components. Tourette syndrome is …

Prior efforts to image cholinergic projections in human brain in vivo had significant technical
limitations. We used the vesicular acetylcholine transporter (VAChT) ligand [18F] …