[HTML][HTML] Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review
N Singh, A Miner, L Hennis, S Mittal - Cancer drug resistance, 2021 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
Inflammation-induced DNA damage, mutations and cancer
The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …
connection linking inflammation to cancer development is DNA damage. During …
DNA damage, DNA repair, aging, and neurodegeneration
Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …
Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response
S Hombach-Klonisch, M Mehrpour, S Shojaei… - Pharmacology & …, 2018 - Elsevier
Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …
Temozolomide: mechanisms of action, repair and resistance
J Zhang, M FG Stevens… - Current molecular …, 2012 - ingentaconnect.com
Glioblastoma multiforme is the most common aggressive adult primary tumour of the central
nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide …
nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide …
Temozolomide and other alkylating agents in glioblastoma therapy
H Strobel, T Baisch, R Fitzel, K Schilberg, MD Siegelin… - Biomedicines, 2019 - mdpi.com
The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and
focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly …
focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly …
[HTML][HTML] DNA methylation, its mediators and genome integrity
H Meng, Y Cao, J Qin, X Song, Q Zhang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT …
Resistance to alkylating agents via direct DNA repair by O6-methylguanine
methyltransferase (MGMT) remains a significant barrier to the successful treatment of …
methyltransferase (MGMT) remains a significant barrier to the successful treatment of …
[HTML][HTML] Updates in IDH-wildtype glioblastoma
JM Melhem, J Detsky, MJ Lim-Fat, JR Perry - Neurotherapeutics, 2022 - Elsevier
Glioblastoma is the most aggressive primary brain tumor with a poor prognosis. The 2021
WHO CNS5 classification has further stressed the importance of molecular signatures in …
WHO CNS5 classification has further stressed the importance of molecular signatures in …
Overview of base excision repair biochemistry
YJ Kim, DM Wilson III - Current molecular pharmacology, 2012 - ingentaconnect.com
Base excision repair (BER) is an evolutionarily conserved pathway, which could be
considered the “workhorse” repair mechanism of the cell. In particular, BER corrects most …
considered the “workhorse” repair mechanism of the cell. In particular, BER corrects most …