High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

The gasotransmitters are a family of gaseous signaling molecules which are produced
endogenously and act at specific receptors to play imperative roles in physiologic and …

Men have higher blood pressure than women through much of life regardless of race and
ethnicity. This is a robust and highly conserved sex difference that it is also observed across …

Purpose: To review the physiologic role of nitric oxide, an unusual messenger molecule that
mediates blood vessel relaxation, neurotransmission, and pathogen suppression. Data …

Blood vessels are under constant mechanical loading from blood pressure and flow which
cause internal stresses (endothelial shear stress and circumferential wall stress …

Nitric oxide produced in endothelial cells affects vascular tone. To investigate the role of
endothelial nitric oxide synthase (eNOS) in blood pressure regulation, we have generated …

Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor
(serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue …

Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …

▪ Abstract The product of nitric oxide (NO) synthase is the most potent endogenous
vasodilator known. NO not only is a potent vasodilator, it also inhibits platelet adherence and …