ZAP-70: an essential kinase in T-cell signaling
H Wang, TA Kadlecek… - Cold Spring …, 2010 - cshperspectives.cshlp.org
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events
involved in initiating T-cell responses by the antigen receptor. Here we review the structure …
involved in initiating T-cell responses by the antigen receptor. Here we review the structure …
A story of kinases and adaptors: The role of LCK, ZAP-70 and LAT in switch panel governing T-cell development and activation
LM Fernández-Aguilar, I Vico-Barranco… - Biology, 2023 - mdpi.com
Simple Summary Tyrosine phosphorylation is the first biochemical event that occurs after
TCR engagement, which is crucial for T-cell development, activation and differentiation …
TCR engagement, which is crucial for T-cell development, activation and differentiation …
ZAP-70 enhances B-cell–receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells
Expression of ZAP-70 is an important negative prognostic factor in chronic lymphocytic
leukemia (CLL). This protein tyrosine kinase is a key mediator of T-cell receptor (TCR) …
leukemia (CLL). This protein tyrosine kinase is a key mediator of T-cell receptor (TCR) …
GATA-3 regulates the development and function of invariant NKT cells
Although invariant NKT (iNKT) cells participate in many aspects of immune responses, the
molecular mechanisms regulating their development, maturation, and activation are still …
molecular mechanisms regulating their development, maturation, and activation are still …
Molecular mechanisms for adaptive tolerance and other T cell anergy models
S Choi, RH Schwartz - Seminars in immunology, 2007 - Elsevier
Since the original description of T cell anergy in CD4 clones from mice and humans, a
number of different unresponsive states have been described, both in vivo and in vitro, that …
number of different unresponsive states have been described, both in vivo and in vitro, that …
ZAP70: a master regulator of adaptive immunity
A Fischer, C Picard, K Chemin, S Dogniaux… - Seminars in …, 2010 - Springer
The protein tyrosine kinase ZAP70 became the subject of intense scrutiny in the early
nineties, when ZAP70 mutations were characterized in several young patients presenting …
nineties, when ZAP70 mutations were characterized in several young patients presenting …
Coronin-1A links cytoskeleton dynamics to TCRαβ-induced cell signaling
B Mugnier, B Nal, C Verthuy, C Boyer, D Lam… - PloS one, 2008 - journals.plos.org
Actin polymerization plays a critical role in activated T lymphocytes both in regulating T cell
receptor (TCR)-induced immunological synapse (IS) formation and signaling. Using gene …
receptor (TCR)-induced immunological synapse (IS) formation and signaling. Using gene …
Endogenous retroviral pathogenesis in lupus
A Perl, D Fernandez, T Telarico… - Current opinion in …, 2010 - journals.lww.com
Endogenous retroviral pathogenesis in lupus : Current Opinion in Rheumatology
Endogenous retroviral pathogenesis in lupus : Current Opinion in Rheumatology Log in or …
Endogenous retroviral pathogenesis in lupus : Current Opinion in Rheumatology Log in or …
Functional T cell immunodeficiencies (with T cells present)
LD Notarangelo - Annual review of immunology, 2013 - annualreviews.org
Severe combined immunodeficiency (SCID) comprises a group of disorders that are fatal
owing to genetic defects that abrogate T cell development. Numerous related defects have …
owing to genetic defects that abrogate T cell development. Numerous related defects have …
Phenotypic models of CAR T-cell activation elucidate the pivotal regulatory role of CAR downmodulation
R Greenman, Y Pizem, M Haus-Cohen, G Horev… - Molecular Cancer …, 2021 - AACR
Adoptive cell immunotherapy with chimeric antigen receptor (CAR) showed limited potency
in solid tumors, despite durable remissions for hematopoietic malignancies. Therefore, an …
in solid tumors, despite durable remissions for hematopoietic malignancies. Therefore, an …