The role of peroxisome proliferator‐activated receptor γ in lipid metabolism and inflammation in atherosclerosis

X Yang, D Shang - Cell Biology International, 2023 - Wiley Online Library
Cardiovascular disease events are the result of functional and structural abnormalities in the
arteries and heart. Atherosclerosis is the main cause and pathological basis of …

PPAR-γ partial agonists in disease-fate decision with special reference to cancer

S Ballav, B Biswas, VK Sahu, A Ranjan, S Basu - Cells, 2022 - mdpi.com
Peroxisome proliferator-activated receptor-γ (PPAR-γ) has emerged as one of the most
extensively studied transcription factors since its discovery in 1990, highlighting its …

Lactococcus lactis subspecies cremoris elicits protection against metabolic changes induced by a western-style diet

CR Naudin, K Maner-Smith, JA Owens, GM Wynn… - Gastroenterology, 2020 - Elsevier
Background & Aims A Western-style diet, which is high in fat and sugar, can cause
significant dyslipidemia and nonalcoholic fatty liver disease; the diet has an especially …

Oxidized lipids in persistent pain states

T Osthues, M Sisignano - Frontiers in pharmacology, 2019 - frontiersin.org
Chemotherapy, nerve injuries, or diseases like multiple sclerosis can cause
pathophysiological processes of persistent and neuropathic pain. Thereby, the activation …

[Retracted] The Role of 12/15‐Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory …

R Tan, B Yan, C Wang, L Zhang - BioMed Research …, 2022 - Wiley Online Library
12/15‐lipoxygenase (12/15‐LOX) is a member of the lipoxygenase family, which can
catalyze a variety of polyunsaturated fatty acids (PUFA) to produce different metabolites …

The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi

J Revol-Cavalier, A Quaranta, JW Newman… - Chemical …, 2024 - ACS Publications
The octadecanoids are a broad class of lipids consisting of the oxygenated products of 18-
carbon fatty acids. Originally referring to production of the phytohormone jasmonic acid, the …

Detoxification Cytochrome P450s (CYPs) in Families 1–3 Produce Functional Oxylipins from Polyunsaturated Fatty Acids

JA Eccles, WS Baldwin - Cells, 2022 - mdpi.com
This manuscript reviews the CYP-mediated production of oxylipins and the current known
function of these diverse set of oxylipins with emphasis on the detoxification CYPs in families …

Hepatotoxicity study of combined exposure of DEHP and ethanol: A comprehensive analysis of transcriptomics and metabolomics

Y Li, Q Zhang, J Fang, N Ma, X Geng, M Xu… - Food and Chemical …, 2020 - Elsevier
Abstract Both di (2-ethylhexyl) phthalate (DEHP) and ethanol have toxic effects on the liver,
and the oral exposure to DEHP in combination with ethanol may exist in the alcohol …

Comprehensive analysis of PPARγ agonist activities of stereo-, regio-, and enantio-isomers of hydroxyoctadecadienoic acids

A Umeno, M Sakashita, S Sugino, K Murotomi… - Bioscience …, 2020 - portlandpress.com
Hydroxyoctadecadienoic acids (HODEs) are produced by oxidation and reduction of
linoleates. There are several regio-and stereo-isomers of HODE, and their concentrations in …

9-HODE and 9-HOTrE alter mitochondrial metabolism, increase triglycerides, and perturb fatty acid uptake and synthesis associated gene expression in HepG2 cells

WA Evans, JA Eccles-Miller, E Anderson… - … and Essential Fatty …, 2024 - Elsevier
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) prevalence is rising and can lead to
detrimental health outcomes such as Non-Alcoholic Steatohepatitis (NASH), cirrhosis, and …