Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

DNA damage is a key factor both in the evolution and treatment of cancer. Genomic
instability is a common feature of cancer cells, fuelling accumulation of oncogenic mutations …

Background Olaparib, a novel, orally active poly (ADP-ribose) polymerase (PARP) inhibitor,
induced synthetic lethality in BRCA-deficient cells. A maximum tolerated dose and initial …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to
breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a …

Purpose Secondary somatic BRCA1/2 mutations may restore BRCA1/2 protein in hereditary
ovarian carcinomas. In cell lines, BRCA2 restoration mediates resistance to platinum …

Ovarian carcinomas with mutations in the tumour suppressor BRCA2 are particularly
sensitive to platinum compounds. However, such carcinomas ultimately develop cisplatin …

Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose
individuals to breast and ovarian cancers. Progress in determining the function of BRCA1 …

Abnormalities precipitated by a targeted truncation in the murine gene Brca2 define its
involvement in DNA repair. In culture, cells harboring truncated Brca2 exhibit a proliferative …

Although ovarian carcinomas with mutated BRCA1 or BRCA2 are sensitive to platinum
compounds, such carcinomas eventually develop platinum resistance. Previously, we …