Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …

Transformed cells adapt metabolism to support tumor initiation and progression. Specific
metabolic activities can participate directly in the process of transformation or support the …

Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that
photoredox catalysis can provide an oxygen-independent mechanism of action to combat …

The past decades have witnessed significant efforts toward the development of three-
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …

In comparison with 2D cell culture models, 3D spheroids are able to accurately mimic some
features of solid tumors, such as their spatial architecture, physiological responses …

In vitro drug screening is widely used in the development of new drugs, because they
constitute a cost-effective approach to select compounds with more potential for therapy …

Three-dimensional cell cultures using patient-derived stem cells are essential in vitro
models for a more efficient and individualized cancer therapy. Currently, culture conditions …

Three-dimensional (3D) culture systems have fueled hopes to bring about the next
generation of more physiologically relevant high-throughput screens (HTS). However …

The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

New cancer drug approval rates are≤ 5% despite significant investments in cancer
research, drug discovery and development. One strategy to improve the rate of success of …