Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
Chemokines, molecular drivers of thromboinflammation and immunothrombosis
J Leberzammer, P von Hundelshausen - Frontiers in Immunology, 2023 - frontiersin.org
Blood clotting is a finely regulated process that is essential for hemostasis. However, when
dysregulated or spontaneous, it promotes thrombotic disorders. The fact that these are …
dysregulated or spontaneous, it promotes thrombotic disorders. The fact that these are …
The multifaceted role of platelets in mediating brain function
Platelets, the small, anucleate blood cells that originate from megakaryocytes in the bone
marrow, are typically associated with coagulation. However, it is now apparent that platelets …
marrow, are typically associated with coagulation. However, it is now apparent that platelets …
[HTML][HTML] Alpha‐2‐macroglobulin in hemostasis and thrombosis: an underestimated old double‐edged sword
Antiproteinases such as alpha‐2‐macroglobulin (A2M) play a role in hemostasis. A2M is
highly conserved throughout evolution and is a high molecular weight homo‐tetrameric …
highly conserved throughout evolution and is a high molecular weight homo‐tetrameric …
Angiogenesis and tissue repair depend on platelet dosing and bioformulation strategies following orthobiological platelet-rich plasma procedures: a narrative review
Angiogenesis is the formation of new blood vessel from existing vessels and is a critical first
step in tissue repair following chronic disturbances in healing and degenerative tissues …
step in tissue repair following chronic disturbances in healing and degenerative tissues …
[HTML][HTML] Multi-omics approaches to study platelet mechanisms
FA Solari, D Krahn, F Swieringa, S Verhelst… - Current Opinion in …, 2023 - Elsevier
Platelets are small anucleate cell fragments (2–4 μm in diameter) in the blood, which play an
essential role in thrombosis and hemostasis. Genetic or acquired platelet dysfunctions are …
essential role in thrombosis and hemostasis. Genetic or acquired platelet dysfunctions are …
Targeting platelet-derived CXCL12 impedes arterial thrombosis
J Leberzammer, SM Agten, X Blanchet… - Blood, The Journal …, 2022 - ashpublications.org
The prevention and treatment of arterial thrombosis continue to be clinically challenging,
and understanding the relevant molecular mechanisms in detail may facilitate the quest to …
and understanding the relevant molecular mechanisms in detail may facilitate the quest to …
Molecular basis of clot retraction and its role in wound healing
AT Nurden - Thrombosis Research, 2023 - Elsevier
Clot retraction is important for the prevention of bleeding, in the manifestations of thrombosis
and for tissue repair. The molecular mechanisms behind clot formation are complex. Platelet …
and for tissue repair. The molecular mechanisms behind clot formation are complex. Platelet …
Molecular proteomics and signalling of human platelets in health and disease
Platelets are small anucleate blood cells that play vital roles in haemostasis and thrombosis,
besides other physiological and pathophysiological processes. These roles are tightly …
besides other physiological and pathophysiological processes. These roles are tightly …
Crucial roles of red blood cells and platelets in whole blood thrombin generation
S Sun, E Campello, J Zou, J Konings… - Blood …, 2023 - ashpublications.org
Red blood cells (RBCs) and platelets contribute to the coagulation capacity in bleeding and
thrombotic disorders. The thrombin generation (TG) process is considered to reflect the …
thrombotic disorders. The thrombin generation (TG) process is considered to reflect the …