Bacterial populations produce a small number of dormant persister cells that exhibit
multidrug tolerance. All resistance mechanisms do essentially the same thing: prevent the …

Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

The nematode Caenorhabditis elegans is a unique whole animal model system for
identifying small molecules with in vivo anti-infective properties. C. elegans can be infected …

The modern era of antibacterial chemotherapy began in the 1930s, and the next four
decades saw the discovery of almost all the major classes of antibacterial agents that are …

Natural products and their derivatives have been and continue to be rich sources for drug
discovery. However, natural products are not drugs. They are produce in nature and through …

In the past few years macromolecular crystallography has become a standard technique
used by many pharmaceutical and biotechnology companies. This methodology offers …

Large-scale screening of hundreds or even thousands of crystallization conditions while with
low sample consumption is in urgent need, in current structural biology research. Here we …

Bacterial resistance continues to develop and pose a significant threat, both in hospitals
and, more recently, in the community. A focus on other therapeutic areas by the larger …

Objectives This study was performed to analyse in vitro and in vivo activities of CG400549, a
new FabI inhibitor, against clinical isolates of staphylococci. The mode of action of …

A novel series of substituted benzothiazoles, bearing semicarbazone and
thiosemicarbazone moieties, was designed, synthesized and evaluated for their …