Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

INTRODUCTION In human cells, 2 m of DNA are compacted in the nucleus through
assembly with histones and other proteins into chromatin structures, megabase three …

The structure of chromatin plays pivotal roles in regulating gene transcription, DNA
replication and repair, and chromosome segregation. This structure, however, remains …

How a long strand of genomic DNA is compacted into a mitotic chromosome remains one of
the basic questions in biology. The nucleosome fibre, in which DNA is wrapped around core …

Since Flemming described a nuclear substance in the nineteenth century and named it
“chromatin,” this substance has fascinated biologists. What is the structure of chromatin …

Cryo-electron tomography provides low-resolution 3D views of cells, organelles, or viruses.
Macromolecular complexes present in multiple copies can be subsequently identified within …

Cell type specific transcriptional regulation must be adhered to in order to maintain cell
identity throughout the lifetime of an organism, yet it must be flexible enough to allow for …

Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate
DNA processes, including transcription, replication, and repair. Conformational dynamics …

The relationship between the 4D folding of the genome and its function is an outstanding
question in biology. A range of methods that probe the folding of the genome in space and …