Prefrontal cortex metabolome is modified by opioids, anesthesia, and sleep

R Lydic, HA Baghdoyan - Physiology, 2021 - journals.physiology.org
Obtundation of wakefulness caused by opioids and loss of wakefulness caused by
anesthetics and sleep significantly alter concentrations of molecules comprising the …

Fentanyl and neostigmine delivered to mouse prefrontal cortex differentially alter breathing

ZT Glovak, HA Baghdoyan, R Lydic - Respiratory Physiology & …, 2022 - Elsevier
Opioids impair many functions modulated by the prefrontal cortex (PFC), including
wakefulness, cognition, and breathing. In contrast, cholinergic activity in the PFC increases …

Opioid-Induced Respiratory Depression in C57BL/6J Mice: The Role of Prefrontal Cortex Cholinergic Transmission in the Wakefulness Stimulus for Breathing

W Sun - 2022 - trace.tennessee.edu
Opioid-induced respiratory depression (OIRD) is the primary cause of death from opioid
overdose. Opioids depress breathing by diminishing the wakefulness stimulus for breathing …