Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape
tissues, influence social interactions, and protect against pathogens and other …

Apical extracellular matrices (aECMs) coat exposed surfaces of epithelia to shape
developing tissues and protect them from environmental insults. Despite their widespread …

Secoisolariciresinol diglucoside (SDG) is a phytoestrogen and rich in food flaxseed,
sunflower seeds, and sesame seeds. Among the beneficial pharmacological activities of …

The high rate of antibody production places considerable metabolic and folding stress on
plasma cells (PC). Not surprisingly, they rely on the unfolded protein response (UPR), a …

Chaperone expression is developmentally regulated, establishing tissue-specific networks.
However, the molecular basis underlying this specificity is mainly unknown. Recent …

Neurodegenerative diseases like Parkinson's disease (PD) are intimately associated with
oxidative stress due to the excessive highly reactive oxygen species (ROS), leading to the …

Post-translational protein modifications are essential for the spatio-temporal regulation of
protein function. In this study, we examine how the activity of the Caenorhabditis elegans …

Background Temperature influences biology at all levels, from altering rates of biochemical
reactions to determining sustainability of entire ecosystems. Although extended exposure to …

The skeleton is a secretory organ, and the goal of some osteoporosis therapies is to
maximize bone matrix output. Nmp4 encodes a novel transcription factor that regulates bone …

Muscle proteostasis is shaped by the myogenic transcription factor MyoD which regulates
the expression of chaperones during muscle differentiation. Whether MyoD can also …