Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

The forkhead box O (FoxO) transcription factor family is a key player in an evolutionary
conserved pathway downstream of insulin and insulin-like growth factor receptors. The …

Genomic sequencing reveals similar but limited numbers of protein-coding genes in different
genomes, which begs the question of how organismal diversities are generated. Alternative …

Summary mTORC1 is a signal integrator and master regulator of cellular anabolic processes
linked to cell growth and survival. Here, we demonstrate that mTORC1 promotes lipid …

Pre-mRNA splicing is regulated by developmental and environmental cues, but little is
known about how specific signals are transduced in mammalian cells to regulate this critical …

Platelets contain unspliced heteronuclear IL-1β RNA, which is rapidly spliced and translated
upon activation. LPS is a superior agonist for this atypical platelet response, but how LPS …

As viruses do not possess genes encoding for proteins required for translation, energy
metabolism or membrane biosynthesis, they are classified as obligatory intracellular …

Abstract Background The Mnk2 kinase, encoded by MKNK2 gene, plays critical roles in
MAPK signaling and was involved in oncogenesis. Human MKNK2 pre-mRNA can be …