Fractures associated with Type2 diabetes (T2DM) are major public health concerns in an
increasingly obese and aging population. Patients with obesity or T2DM have normal or …

Src, a non-receptor tyrosine kinase, was first discovered as a prototype oncogene and has
been shown to critical for cancer progression for a variety of tissues. Src activity is regulated …

Disuse osteoporosis is characterized by decreased bone mass caused by abnormal
mechanical stimulation of bone. Piezo1 is a major mechanosensitive ion channel in bone …

Bone metabolic homeostasis is dependent on coupled bone formation dominated by
osteoblasts and bone resorption dominated by osteoclasts, which is a process of dynamic …

Epigenetic modification pertains to the alteration of genetic-expression, which could be
transferred to the next generations, without any alteration in the fundamental DNA …

Osteoporosis (OP) is a metabolic bone disease linked to an elevated fracture risk, primarily
stemming from disruptions in bone metabolism. Present clinical treatments for OP merely …

老Ç 草素(Ge) 能够抑制破骨细胞(OC) 的增殖分化和促进成骨细胞(OB) 的增殖分化,
促进骨髓间充质干细胞向成骨分化, 本文通过检索近年来维普, 中国知网, PubMed …

Optineurin (OPTN) is a widely expressed multifunctional articulatory protein that participates
in cellular or mitochondrial autophagy, vesicular transport, and endoplasmic reticulum (ER) …

Glucocorticoid excess causes bone loss due to decreased bone formation and increased
bone resorption; miR-433-3p is a miRNA that negatively regulates bone formation in male …

To investigate the potential association between LRP5 rs648438 polymorphism and the risk
of skeletal fluorosis (SF) was evaluated in a cross-sectional case–control study conducted in …