Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of …

Heterotrimeric GTP‐binding proteins (G proteins) that are made up of α and βγy subunits
couple many kinds of cell‐surface receptors to intracellular effector enzymes or ion …

A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to
specific effector target molecules. The G protein transducin, Gt, couples photon-activated …

Since the first Handbook of Cell-Penetrating Peptides was prepared in 2001, the wealth of
new information on the use of these peptides as transport systems has in fact served to …

The G protein transducin has been an often-used model for biochemical, structural, and
mechanistic studies of G protein function. Experimental studies have been limited, however …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

Regulatory proteins are the instruments which allow cells to communicate with the
environment [1]. In the large family of G-protein-coupled signal transduction systems …

Cyclic nucleotide phosphodiesterases (PDEs) work in conjunction with adenylate/guanylate
cyclases to regulate the key second messengers of G protein–coupled receptor signaling …

Phototransduction in retinal rods occurs when the G protein–coupled photoreceptor
rhodopsin triggers the activation of phosphodiesterase 6 (PDE6) by GTP-bound alpha …

The central effector of visual transduction in retinal rod photoreceptors, cGMP
phosphodiesterase (PDE6), is a catalytic heterodimer (αβ) to which low molecular weight …