The immunology of sepsis
T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …
response to an infection. This recently implemented definition does not capture the …
Incidence and mortality of hospital-and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis
C Fleischmann-Struzek, L Mellhammar, N Rose… - Intensive care …, 2020 - Springer
Purpose To investigate the global burden of sepsis in hospitalized adults by updating and
expanding a systematic review and meta-analysis and to compare findings with recent …
expanding a systematic review and meta-analysis and to compare findings with recent …
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …
Characterisation of the first 250 000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data
Background Most low-income and middle-income countries (LMICs) have little or no data
integrated into a national surveillance system to identify characteristics or outcomes of …
integrated into a national surveillance system to identify characteristics or outcomes of …
[HTML][HTML] Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
KE Rudd, SC Johnson, KM Agesa, KA Shackelford… - The Lancet, 2020 - thelancet.com
Background Sepsis is life-threatening organ dysfunction due to a dysregulated host
response to infection. It is considered a major cause of health loss, but data for the global …
response to infection. It is considered a major cause of health loss, but data for the global …
Biomarkers of sepsis: time for a reappraisal
Introduction Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic
functions. In a previous review, we identified 3370 references reporting on 178 different …
functions. In a previous review, we identified 3370 references reporting on 178 different …
Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis
R Markwart, H Saito, T Harder, S Tomczyk… - Intensive care …, 2020 - Springer
Purpose Sepsis is recognized as a global public health problem, but the proportion due to
hospital-acquired infections remains unclear. We aimed to summarize the epidemiological …
hospital-acquired infections remains unclear. We aimed to summarize the epidemiological …
Adjunctive glucocorticoid therapy in patients with septic shock
Background Whether hydrocortisone reduces mortality among patients with septic shock is
unclear. Methods We randomly assigned patients with septic shock who were undergoing …
unclear. Methods We randomly assigned patients with septic shock who were undergoing …
[HTML][HTML] Clinical course and outcomes of critically ill patients with COVID-19 infection: a systematic review
RB Serafim, P Póvoa, V Souza-Dantas, AC Kalil… - Clinical Microbiology …, 2021 - Elsevier
Abstract Objectives Coronavirus disease 19 (COVID-19) is a major cause of hospital
admission and represents a challenge for patient management during intensive care unit …
admission and represents a challenge for patient management during intensive care unit …
[HTML][HTML] Sepsis: evolving concepts and challenges
Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden
in low-and middle-resource settings. The role of the inflammatory response in the …
in low-and middle-resource settings. The role of the inflammatory response in the …