Blood-spinal cord barrier disruption in degenerative cervical myelopathy

HW Kim, H Yong, GKH Shea - Fluids and Barriers of the CNS, 2023 - Springer
Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord
dysfunction in the aging population. Significant neurological deficits may result from a …

Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression

M Yao, P Pu, Z Li, K Zhu, L Zhou, YL Sun… - Journal of pineal …, 2023 - Wiley Online Library
Cervical spondylotic myelopathy (CSM) refers to a chronic injury of the cervical cord caused
by cervical intervertebral disc degeneration. Endoplasmic reticulum (ER) homeostasis is …

Chronic spinal cord compression associated with intervertebral disc degeneration in SPARC-null mice

ZY Li, AF Zhou, G Li, LY Zhou, PM Pu… - Neural Regeneration …, 2023 - journals.lww.com
Chronic spinal cord compression (CSCC) is induced by disc herniation and other reasons,
leading to movement and sensation dysfunction, with a serious impact on quality of life …

[HTML][HTML] Network pharmacology analysis and animal experiment validation of neuroinflammation inhibition by total ginsenoside in treating CSM

Z Li, Y Dai, Z Wu, G Li, P Pu, C Hu, L Zhou, K Zhu… - Phytomedicine, 2024 - Elsevier
Background Cervical spondylotic myelopathy (CSM) is a degenerative pathology that affects
both upper and lower extremity mobility and sensory function, causing significant pressure …

Shenqisherong pill ameliorates neuronal apoptosis by inhibiting the JNK/caspase-3 signaling pathway in a rat model of cervical cord compression

K Zhu, P Pu, G Li, L Zhou, Z Li, Q Shi, Y Wang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance The Shenqisherong (SQSR) pill is an empirical
prescription of traditional Chinese medicine (TCM), which originated from the National …

Ischemia–reperfusion injury after spinal cord decompressive surgery—An in vivo rat model

B Zhang, Z Jin, P Luo, H Yin, X Chen… - Animal Models and …, 2024 - Wiley Online Library
Background Although decompression surgery is the optimal treatment for patients with
severe degenerative cervical myelopathy (DCM), some individuals experience no …

[HTML][HTML] Analysis of gene expression profiles and experimental validations of a rat chronic cervical cord compression model

P Pu, Z Li, Y Dai, Y Sun, Y Wang, X Cui… - Neurochemistry …, 2023 - Elsevier
Cervical spondylotic myelopathy (CSM) is a severe non-traumatic spinal cord injury (SCI)
wherein the spinal canal and cervical cord are compressed due to the degeneration of …

[HTML][HTML] Natural agents that are neuroprotective against mitochondria: a bibliometric-based research mapping 1998–2024, from cells to mitochondria

AY SALEH, DAY Saputra - F1000Research, 2024 - f1000research.com
Introduction Mitochondria are cell organelles that function as the cell's main power plant,
producing ATP, the main energy molecule in cells. Mitochondria play an important role in the …

Potential chemical inhibitors of inflammasomes modulate microglial and astrocytic functions

BK Greuel - 2023 - open.library.ubc.ca
Alzheimer's disease (AD) is the sixth leading cause of death worldwide and is characterized
by chronic neuroinflammation. Microglia are the brain immunocytes, which normally support …

Effects of Massage on Neuro-Vascular Regulation and Apoptosis in Rabbits with Cervical Spondylosis of the Vertebral Artery Type

C Wang, H Xu, Y Xiong, Y Su, Y Li, J Zhu - 2023 - researchsquare.com
Objective To explore the therapeutic mechanisms of massage for cervical spondylosis of
vertebral artery type (CSA) from the effects of sympathetic neurotransmitter changes on …