Targeting copper in cancer imaging and therapy: a new theragnostic agent

G Capriotti, A Piccardo, E Giovannelli… - Journal of Clinical …, 2022 - mdpi.com
Copper is required for cancer cell proliferation and tumor angiogenesis. Copper-64
radionuclide (64Cu), a form of copper chloride (64CuCl2), is rapidly emerging as a …

[HTML][HTML] Recent Advances in Preclinical Studies of the Theranostic Agent [64Cu]CuCl2

G Speltri, F Porto, A Boschi, L Uccelli, P Martini - Molecules, 2024 - mdpi.com
64Cu is gaining recognition not only for its diagnostic capabilities in nuclear medical
imaging but also for its therapeutic and theranostic potential. The simultaneous βˉ and …

Cobaltabis(dicarbollide) ([o-COSAN]) as Multifunctional Chemotherapeutics: A Prospective Application in Boron Neutron Capture Therapy (BNCT) for Glioblastoma

M Nuez-Martinez, CIG Pinto, JF Guerreiro, F Mendes… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma multiforme (GBM) is one of the most common malignant
brain tumors. Although a variety of GBMs is initially susceptible to chemotherapy, the …

Let's Go 3D! New Generation of Models for Evaluating Drug Response and Resistance in Prostate Cancer

T Petrić, M Sabol - International Journal of Molecular Sciences, 2023 - mdpi.com
Prostate cancer (PC) is the third most frequently diagnosed cancer worldwide and the
second most frequent in men. Several risk factors can contribute to the development of PC …

64CuCl2 PET Imaging of 4T1-Related Allograft of Triple-Negative Breast Cancer in Mice

A Latgé, F Boisson, A Ouadi, G Averous, L Thomas… - Molecules, 2022 - mdpi.com
64CuCl2 is an economic radiotracer for oncologic PET investigations. In the present study,
we characterized the uptake of 64CuCl2 in vivo by µPET/CT in an allograft 4T1-related …

Recent Advances in Cancer Imaging with 64CuCl2 PET/CT

F Peng - Nuclear Medicine and Molecular Imaging, 2022 - Springer
Copper is required for cancer cell proliferation and tumor angiogenesis. Radioactive copper-
64 chloride (64CuCl2) is a useful radiotracer for cancer imaging with position emission …

64Cu2+ Complexes of Tripodal Amine Ligands' In Vivo Tumor and Liver Uptakes and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line …

M Shinada, M Takahashi, C Igarashi, H Matsumoto… - Pharmaceuticals, 2024 - mdpi.com
Copper (Cu) is a critical element for cancer cell proliferation and considerably accumulates
in the nucleus. 64Cu2+ is an anticancer radiopharmaceutical that targets the copper …

Modifications in cellular viability, DNA damage and stress responses inflicted in cancer cells by copper-64 ions

RM Serban, D Niculae, G Manda, I Neagoe… - Frontiers in …, 2023 - frontiersin.org
Due to combined therapeutical emissions, a high linear energy transfer Auger-electrons with
the longer ranged β− particles, 64Cu-based radiopharmaceuticals raise particular …

Evaluation of the theranostic potential of [64Cu]CuCl2 in glioblastoma spheroids

CIG Pinto, ADM Branco, S Bucar, A Fonseca… - EJNMMI research, 2024 - Springer
Background Glioblastoma is an extremely aggressive malignant tumor with a very poor
prognosis. Due to the increased proliferation rate of glioblastoma, there is the development …

Radiobiological Assessment of Targeted Radionuclide Therapy with [177Lu]Lu-PSMA-I&T in 2D vs. 3D Cell Culture Models

J Raitanen, B Barta, H Fuchs, M Hacker… - International Journal of …, 2023 - mdpi.com
In vitro therapeutic efficacy studies are commonly conducted in cell monolayers. However,
three-dimensional (3D) tumor spheroids are known to better represent in vivo tumors. This …