The large-conductance, calcium-activated potassium channels (BK, also termed BKCa, Slo,
or MaxiK) distributed in both excitable and non-excitable cells are involved in many cellular …

A number of ion channels and transporters are expressed in both the inner ear and kidney.
In the inner ear, K+ cycling and endolymphatic K+, Na+, Ca2+, and pH homeostasis are …

The distal tubule of the mammalian kidney can be defined as the nephron segment between
the macula densa region and the cortical collecting tubule. It comprises several …

Ca2+-and voltage-gated K+ channels of large conductance (BK channels) are expressed in
a diverse variety of both excitable and inexcitable cells, with functional properties …

The discovery of the renal outer medullary K+ channel (ROMK, Kir1. 1), the founding
member of the inward-rectifying K+ channel (Kir) family, by Ho and Hebert in 1993 …

Gain/loss of function studies were utilized to assess the potential role of the endogenous
vanilloid receptor TRPV4 as a sensor of flow and osmolality in M-1 collecting duct cells …

The kidney is a remarkable organ that accomplishes the challenge of removing waste from
the body and simultaneously regulating electrolyte and water balance. Pro-urine flows …

Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na+, K+,
and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is an active …

The kidney is the major regulator of potassium homeostasis. In addition to the ROMK
channels, large conductance Ca 2+-activated K+(BK) channels are expressed in the apical …

WNK kinases are serine-threonine kinases with an atypical placement of the catalytic lysine.
Intronic deletions with increased expression of a ubiquitous long WNK1 transcript cause …