The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

Summary SHH subgroup medulloblastoma (SHH-MB) is one of the most common malignant
pediatric tumors that arises in the cerebellum. Previously, we showed that RNA m 6 A …

A cohort of genes associated with embryonic stem (ES) cell behaviour, including NANOG,
are expressed in a number of human cancers. They form an ES‐like signature we first …

Growth of basal cell carcinomas (BCCs) requires high levels of hedgehog (HH) signalling
through the transcription factor GLI. Although inhibitors of membrane protein smoothened …

Hedgehog signaling drives oncogenesis in several cancers, and strategies targeting this
pathway have been developed, most notably through inhibition of Smoothened (SMO) …

Sonic hedgehog (Shh) signaling plays a critical role in regulating cerebellum development
by maintaining the physiological proliferation of granule neuron precursors (GNPs), and its …

Canonical Hedgehog (HH) signaling leads to the regulation of the GLI code: the sum of all
positive and negative functions of all GLI proteins. In humans, the three GLI factors encode …

Tumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to
targeted cancer therapies. Basal cell carcinomas (BCCs) depend on Hedgehog (Hh)/Gli …

Hedgehog pathway–dependent cancers can escape Smoothened (SMO) inhibition through
mutations in genes encoding canonical hedgehog pathway components; however, around …