Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection

D Yang, M Ding, Y Song, Y Hu, W Xiu… - Biomaterials …, 2023 - spj.science.org
The advent of drug-resistant pathogens results in the occurrence of stubborn bacterial
infections that cannot be treated with traditional antibiotics. Antibacterial immunotherapy by …

The emergence of cancer sono-immunotherapy

Y Yang, Y Cheng, L Cheng - Trends in Immunology, 2024 - cell.com
Owing to its remarkable ease of use, ultrasound has recently been explored for stimulating
or amplifying immune responses during cancer therapy, termed 'sono-immunotherapy' …

Supramolecular Photothermal Cascade Nano‐Reactor Enables Photothermal Effect, Cascade Reaction, and In Situ Hydrogelation for Biofilm‐Associated Tooth …

L Chen, M Peng, J Zhou, X Hu, Y Piao, H Li… - Advanced …, 2023 - Wiley Online Library
Due to the emergence of drug resistance in bacteria and biofilm protection, achieving a
satisfactory therapeutic effect for bacteria‐infected open wounds with conventional …

Biomaterials for in situ cell therapy

C Wang, S Wang, DD Kang, Y Dong - BMEMat, 2023 - Wiley Online Library
Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic
disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo …

Macrophage-membrane-camouflaged nonviral gene vectors for the treatment of multidrug-resistant bacterial sepsis

H Cao, Y Gao, H Jia, L Zhang, J Liu, G Mu, H Gui… - Nano Letters, 2022 - ACS Publications
Sepsis is a life-threatening disease caused by systemic bacterial infections, with high
morbidity and mortality worldwide. As the standard treatment for sepsis, antibiotic therapy …

Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives

S Zhang, H Yang, M Wang, D Mantovani, K Yang… - The Innovation, 2023 - cell.com
Bacterial infectious diseases are one of the leading causes of death worldwide. Even with
the use of multiple antibiotic treatment strategies, 4.95 million people died from drug …

PTT/PDT-induced microbial apoptosis and wound healing depend on immune activation and macrophage phenotype transformation

H Chen, L Wu, T Wang, F Zhang, J Song, J Fu, X Kong… - Acta biomaterialia, 2023 - Elsevier
Antibiotics show unsuccessful application in biofilm destruction, which induce chronic
infections and emergence of antibiotic resistant bacteria. Photodynamic therapy (PDT) and …

Transformable nano-antibiotics for mechanotherapy and immune activation against drug-resistant Gram-negative bacteria

RS Li, J Liu, C Wen, Y Shi, J Ling, Q Cao, L Wang… - Science …, 2023 - science.org
The dearth of antibiotic candidates against Gram-negative bacteria and the rise of antibiotic
resistance create a global health concern. The challenge lies in the unique Gram-negative …

[HTML][HTML] Metal-fluorouracil networks with disruption of mitochondrion enhanced ferroptosis for synergistic immune activation

L Lei, Z Dong, L Xu, F Yang, B Yin, Y Wang, R Yue… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Ferroptosis drugs inducing cancer immunogenic cell death (ICD) have shown the
potential of immunotherapy in vivo. However, the current ferroptosis drugs usually induce …

[HTML][HTML] Advances in the antimicrobial treatment of osteomyelitis

C Zhong, Y Wu, H Lin, R Liu - Composites Part B: Engineering, 2023 - Elsevier
Osteomyelitis is a major complication of orthopedic diseases with high recurrence and
morbidity, along with long hospital stays and high medical costs. The conventional treatment …