Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal
insufficiency more than 80 years ago, glucocorticoids (GC) and their cognate, intracellular …

Our goal in this review is to discuss how measures beyond simple quantification of total
glucocorticoid levels are needed in comparative studies of stress. We need to measure …

Identifying signals in the tumor microenvironment (TME) that shape CD8+ T cell phenotype
can inform novel therapeutic approaches for cancer. Here, we identified a gradient of …

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …

Mood and anxiety disorders are prevalent conditions affecting one out of four people during
lifetime. The development of high validity animal models to study these disorders has been a …

Altered neurogenesis is suggested to be involved in the onset of brain diseases, including
mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for …

We demonstrate that conditional ablation of the homeobox transcription factor Cdx2 from
early endoderm results in the replacement of the posterior intestinal epithelium with …

Circadian clocks are fundamental physiological regulators of energy homeostasis, but direct
transcriptional targets of the muscle clock machinery are unknown. To understand how the …

Glucocorticoids (corticosterone in birds and rodents and cortisol in all other mammals) are
glucoregulatory hormones that are synthesized in response to a range of stimuli including …

The androgen receptor (AR) mediates the physiologic and pathophysiologic effects of
androgens including sexual differentiation, prostate development, and cancer progression …