Ischemic stroke is a devastating brain injury resulting in high mortality and substantial loss of
function. Understanding the pathophysiology of ischemic stroke risk, mortality, and functional …

Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

Can Animal Models of Disease Reliably Inform Human Studies? | PLOS Medicine Skip to main
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Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Traumatic brain injury (TBI) causes secondary biochemical changes that contribute to
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments …

Cerebral palsy is caused by injury or developmental disturbances to the immature brain and
leads to substantial motor, cognitive, and learning deficits. In addition to developmental …

Background: Despite positive preclinical studies and two positive Phase II clinical trials, two
large Phase III clinical trials of progesterone treatment of acute traumatic brain injury (TBI) …

This review considers the pathobiology of non-impact blast-induced neurotrauma (BINT).
The pathobiology of traumatic brain injury (TBI) has been historically studied in experimental …

Progesterone has a broad spectrum of actions in the brain. Among these, the
neuroprotective effects are well documented. Progesterone neural effects are mediated by …

Progesterone is a well-known steroid hormone, synthesized by ovaries and placenta in
females, and by adrenal glands in both males and females. Several tissues are targets of …